![]() ![]() One to 2 mL of the 20% or 2 to 4 mL of the 10% Two to 5 mL of the 20% solution may then be instilled by means of aĪcetylcysteine may also be given through a percutaneous intratracheal catheter. Hours by instillation into the tracheostomy.Īcetylcysteine may be introduced directly into a particular segment of the bronchopulmonary tree by inserting (under local anesthesiaĪnd direct vision) a small plastic catheter into the trachea. When used for the routine nursing care of patients with tracheostomy, 1 to 2 mL of a 10% to 20% solution may be given every 1 to 4 Administration for intermittent or continuous prolonged periods, includingĭirect Instillation: When used by direct instillation, 1 to 2 mL of a 10% to 20% solution may be given as often as every hour. Heavy mist in the tent or Croupette for the desired period. If a tent or Croupette must be used, the recommended dose is the volume of acetylcysteine (using 10 or 20%) that will maintain a very This form ofĪdministration requires very large volumes of the solution, occasionally as much as 300 mL during a single treatment period. Method of use must be individualized to take into account the available equipment and the patient’s particular needs. Nebulization - Tent, Croupette: In special circumstances it may be necessary to nebulize into a tent or Croupette, and this Is 3 to 5 mL of the 20% solution or 6 to 10 mL of the 10% solution three to four times a day. ![]() ML of the 20% solution or 2 to 20 mL of the 10% solution may be given every 2 to 6 hours the recommended dose for most patients Nebulization - Face Mask, Mouthpiece, Tracheostomy: When nebulized into a face mask, mouthpiece, or tracheostomy, 1 to 10 Only a portion of the solution in a vial is used, store the remainder in a refrigerator and use for inhalation only within 96 hours. The 10% solution may be used undiluted.Īcetylcysteine does not contain an antimicrobial agent, and care must be taken to minimize contamination of the sterile solution. ![]() The 20% solution may beĭiluted to a lesser concentration with either Sodium Chloride Injection, Sodium Chloride for Inhalation, Sterile Water for Injection, or DOSAGE AND ADMINISTRATIONģ.1 As adjuvant therapy for patients with abnormal, viscid, or inspissated mucous secretionsĪcetylcysteine Solution, USP is available in rubber stoppered glass vials containing 10 mL or 30 mL. Overdose and, in any case, within 24 hours of ingestion. It is essential to initiate treatment as soon as possible after the Ingestion of a potentially hepatotoxic quantity of acetaminophen. Pulmonary complications associated with surgeryĭiagnostic bronchial studies (bronchograms, bronchospirometry, and bronchial wedge catheterization)ĪCETYLCYSTEINE AS AN ANTIDOTE FOR ACETAMINOPHEN OVERDOSAGEĪcetylcysteine, administered orally, is indicated as an antidote to prevent or lessen hepatic injury which may occur following the ![]() Pulmonary complications of cystic fibrosis Tuberculosis, bronchiectasis and primary amyloidosis of the lung)Īcute bronchopulmonary disease (pneumonia, bronchitis, tracheobronchitis) INDICATIONS AND USAGEĪcetylcysteine is indicated as adjuvant therapy for patients with abnormal, viscid, or inspissated mucous secretions in such conditionsĬhronic bronchopulmonary disease (chronic emphysema, emphysema with bronchitis, chronic asthmatic bronchitis, It is administered by inhalation orĭirect instillation for mucolysis, or orally for acetaminophen overdosage. The pH of the solution ranges from 6.0 to 7.5. Hydroxide and Sterile Water for Injection, USP. Inactive ingredients: edetate disodium, sodium ML) or 20% (200 mg/mL) solution of acetylcysteine as the sodium salt. The compound is a white crystalline powder which melts in the range of 104° to 110☌ and has a very slight odor.Īcetylcysteine Solution, USP is supplied as a sterile unpreserved solution (not for injection) in vials containing a 10% (100 mg/ Molecular formula: C 5H 9NO 3S - Molecular weight: 163.19 Or paracetamol antidote), and available as sterile, unpreserved solutions (not for injection).Īcetylcysteine is the nonproprietary name for the N-acetyl derivative of the naturally occurring amino acid, L-cysteine. Acetylcysteine solution is for inhalation (mucolytic agent) or oral administration (acetaminophen ![]()
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